PMGB

To a suspension of compound containing an acetyl (-COCH₃) group (0.01 mol) in 50 mL of dichloromethane was added m-chloroperbenzoic acid (0.03 mL) in three small portions at room temperature. The resulting mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with 50 mL dichloromethane and washed successively with 2% aqueous sodium thiosulfate (50 mL), saturated aqueous NaHCO₃ solution (2 × 50 mL) and brine (50 mL), dried over MgSO₄ and evaporated to give the corresponding Baeyer-Villager oxidation product (-OCOCH₃) which was purified by triturating with ether. White solid (60%).

Reference: Baeyer-Villager Oxidation

Sosnowski, J. J.; Danaher, E. B.; Murray, R. K. J. Org. Chem. 1985, 50, 2759-2763.

To a suspension of the acetate obtained in the previous step (0.0024 mol) in 4 mL ethanol was added 2 mL 2N aq. NaOH solution. The resulting mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated on rotavapor under reduced pressure and the residue was cooled in ice bath. A few pieces of crushed ice were introduced into the flask and then acidified with 1N HCl solution. The precipitate formed was filtered and washed with water and air dried to give the corresponding phenol. Brown solid (73%).