Comments on: Mono N-methylation http://pmgb.wordpress.com/2008/03/26/mono-n-methylation/ chemical reaction procedures Tue, 10 Nov 2009 16:18:40 +0000 http://wordpress.com/ hourly 1 By: pmgb http://pmgb.wordpress.com/2008/03/26/mono-n-methylation/#comment-34 pmgb Tue, 08 Apr 2008 17:05:20 +0000 http://pmgb.wordpress.com/?p=34#comment-34 Ref: 1.http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/amphetamine.methylation.html and the references there in 2. http://www.alsnotebook.com/reductalk.html (procedure and mechanism) 3. Bhattacharyya, S. Synth. Commun. 1995, 25, 2061-2069. We need the monomethylated product which cannot be accessed by using methyl iodide (overmethylation takes place). Hydrogenation (Pd-C, H2) can also be used to reduce the imine intermediate (see Al's notebook). Ref:
1.http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/amphetamine.methylation.html
and the references there in
2. http://www.alsnotebook.com/reductalk.html (procedure and mechanism)
3. Bhattacharyya, S. Synth. Commun. 1995, 25, 2061-2069.

We need the monomethylated product which cannot be accessed by using methyl iodide (overmethylation takes place).
Hydrogenation (Pd-C, H2) can also be used to reduce the imine intermediate (see Al’s notebook).

]]> By: J.R http://pmgb.wordpress.com/2008/03/26/mono-n-methylation/#comment-33 J.R Tue, 08 Apr 2008 09:59:39 +0000 http://pmgb.wordpress.com/?p=34#comment-33 what is your reference for the quote ......is there a problem with more than mono methylation of the amine? It's assumed also that hydrogenation of the material with Pd as a catalyst will also give the desired mono methylated amine....? what is your reference for the quote ……is there a problem with more than mono methylation of the amine? It’s assumed also that hydrogenation of the material with Pd as a catalyst will also give the desired mono methylated amine….?

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